Clinical research is needed to find cure for conditions that do not have a clear management protocol. It is also paramount that an alternative is provided to ensure that the conditions are put under control as cure is being sought. The aim of research is often to create a new drug, device or establish a non-pharmacological way of curing disease. There are several important concepts on clinical research tampa residents may find interesting.
Before a drug is put on trial, it has to undergo certain processes to ensure it is safe for use in test subjects. Such processes will determine characteristic features of a potential drug including its absorption, distribution, metabolism and excretion from the body. This is referred to as the pharmacokinetics of the drug. Pre-clinical studies also try to find out the pharmacodynamic nature of the substance in question. Pharmacodynamics refer to the reaction of the body to the drug including its desired and adverse side effects. At the end of a pre-clinical study, researchers are in a position to decide just how much of the drug can be tolerated by a given individual.
In some instances, medical equipment is usually the one undergoing scientific studies to facilitate diagnosis and treatment of disease. In this case, the device does not need to go through the initial pre-clinical phase as drugs do. Medical devices instead are taken through what is good laboratory practices with the aim of ascertaining whether the equipment is sustainable in the human body and just how safe it is for use.
In a bid to hasten the research process, an initial step commonly referred to as phase zero was recently put in place. At this stage, the testing is usually done in animals. Moreover, very minute doses are administered. At the end of day, researchers can deduce which drug is promising enough to continue in the trial process.
Phase one of the trial is like the pre-clinical phase only that this time round human beings are used instead of animals. The number of subjects ranges from two to a hundred. This stage takes time to evaluate the dose that is needed to cause desired effect. It is at this stage that the best formulation is decided upon. Safety and toxicity is an additional concern.
Individuals who are healthy are the preferred choice to be used for these studies. People living with advanced cancer are an alternative. Patients who have failed to respond to standard medication are also commonly enrolled in research programs. Ethical guidelines dictate that the individuals signing up for the research receive some financial help to offset any side effects that may occur.
Phase two of research requires the participation of more than a hundred people. This phase mainly tests for efficacy of a drug on a larger number of individuals. The third phase calls for more than a hundred individuals to participate. It is an intensive phase that seeks to prove the value of a therapeutic agent.
The final step is phase four which is mainly a surveillance stage. This step can be used to study additional possibilities such as the effect of certain medication in pregnant women or children. Such special groups are usually hesitant to participate in the earlier stages because of the high risk involved and can only be included after successful tests in healthy adults.
Before a drug is put on trial, it has to undergo certain processes to ensure it is safe for use in test subjects. Such processes will determine characteristic features of a potential drug including its absorption, distribution, metabolism and excretion from the body. This is referred to as the pharmacokinetics of the drug. Pre-clinical studies also try to find out the pharmacodynamic nature of the substance in question. Pharmacodynamics refer to the reaction of the body to the drug including its desired and adverse side effects. At the end of a pre-clinical study, researchers are in a position to decide just how much of the drug can be tolerated by a given individual.
In some instances, medical equipment is usually the one undergoing scientific studies to facilitate diagnosis and treatment of disease. In this case, the device does not need to go through the initial pre-clinical phase as drugs do. Medical devices instead are taken through what is good laboratory practices with the aim of ascertaining whether the equipment is sustainable in the human body and just how safe it is for use.
In a bid to hasten the research process, an initial step commonly referred to as phase zero was recently put in place. At this stage, the testing is usually done in animals. Moreover, very minute doses are administered. At the end of day, researchers can deduce which drug is promising enough to continue in the trial process.
Phase one of the trial is like the pre-clinical phase only that this time round human beings are used instead of animals. The number of subjects ranges from two to a hundred. This stage takes time to evaluate the dose that is needed to cause desired effect. It is at this stage that the best formulation is decided upon. Safety and toxicity is an additional concern.
Individuals who are healthy are the preferred choice to be used for these studies. People living with advanced cancer are an alternative. Patients who have failed to respond to standard medication are also commonly enrolled in research programs. Ethical guidelines dictate that the individuals signing up for the research receive some financial help to offset any side effects that may occur.
Phase two of research requires the participation of more than a hundred people. This phase mainly tests for efficacy of a drug on a larger number of individuals. The third phase calls for more than a hundred individuals to participate. It is an intensive phase that seeks to prove the value of a therapeutic agent.
The final step is phase four which is mainly a surveillance stage. This step can be used to study additional possibilities such as the effect of certain medication in pregnant women or children. Such special groups are usually hesitant to participate in the earlier stages because of the high risk involved and can only be included after successful tests in healthy adults.
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